D0479

Tissue In-Situ Hybridization - CDT Code Guide

Diagnostic/Oral Pathology Laboratory

Overview

CDT code D0479 refers to the procedure of tissue in-situ hybridization, a diagnostic technique used to identify nucleic acids such as DNA and RNA within a tissue sample. This procedure is pivotal in diagnosing various conditions, including the presence of specific microorganisms and tumors. By targeting specific nucleic acid sequences, it provides detailed insights into the genetic material present in the tissue, aiding in accurate diagnosis and treatment planning. Typically, this procedure is used in cases where traditional diagnostic methods are insufficient, offering a more precise understanding of the pathological state. Dental professionals may encounter this procedure in contexts where oral pathology is suspected, requiring a deeper analysis of tissue samples.

When to Use This Code

  • Suspected presence of viral or bacterial infections in oral tissues
  • Identification of specific tumor markers in oral lesions
  • Cases where traditional biopsy results are inconclusive
  • Monitoring known oral pathologies for changes at the molecular level
  • Research studies involving genetic analysis of oral tissues

Documentation Requirements

  • Detailed clinical notes justifying the need for in-situ hybridization
  • A copy of the pathology report with interpretation
  • Patient consent for the procedure
  • Clear documentation of the tissue sample source
  • Specific nucleic acid targets identified during the procedure
  • Results interpretation and its implications for patient care

Billing Considerations

When billing for D0479, ensure that the procedure is medically necessary and supported by clinical documentation. Be aware of any frequency limitations imposed by insurance providers. Modifiers may be required if the procedure is part of a more extensive diagnostic workup. Verify coverage with the patient's insurance, as some may require prior authorization.

Related CDT Codes

Frequently Asked Questions

The primary purpose is to identify specific nucleic acids within a tissue sample, aiding in the diagnosis of infections and tumors.

Source: CDT 2023 © American Dental Association

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